RT Journal Article
SR Electronic
T1 The intraocular penetration of cefuroxime after parenteral administration.
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 687
OP 689
DO 10.1136/bjo.63.10.687
VO 63
IS 10
A1 A B Richards
A1 A J Bron
A1 B McLendon
A1 M R Kennedy
A1 S R Walker
YR 1979
UL http://bjo.bmj.com/content/63/10/687.abstract
AB Cefuroxime (Zinacef) is a new second generation cephalosporin which is resistant to beta-lactamases produced by both Gram-negative and Gram-positive organisms, with an antibacterial spectrum that includes practically all likely ocular pathogens except pseudomonas. It is shown to penetrate into the eye after intravenous (1.5g) or intramuscular (1 g) injection and achieve therapeutic concentrations, with absence of side effects. Cefuroxime is therefore a useful antibiotic for ophthalimic infections and should have a role in combination with gentamicin in intraocular infections, particularly those of unknown aetiology.