PT  - JOURNAL ARTICLE
AU  - A G Secchi
AU  - I Fregona
AU  - F D'Ermo
TI  - Lysophosphatidyl choline in the aqueous humour during ocular inflammation.
AID  - 10.1136/bjo.63.11.768
DP  - 1979 Nov 01
TA  - British Journal of Ophthalmology
PG  - 768--770
VI  - 63
IP  - 11
4099  - http://bjo.bmj.com/content/63/11/768.short
4100  - http://bjo.bmj.com/content/63/11/768.full
SO  - Br J Ophthalmol1979 Nov 01; 63
AB  - Phospholipase A and lysophosphatidyl choline (LPC) have been shown to induce significant changes in the lens permeability in vitro to cations and soluble proteins. During uveal inflammation, in various experimental models and in man as well, the levels of LPC in the aqueous humour have been shown to reach values which are harmful to the lens in vitro. In addition, a phospholipase is thought to be activated during the antigen + antibody + complement sequence. The possible significance of these findings is discussed in relation to the pathogenesis of complicated cataracts in uveitis and the possible role of the lens as a source of autoantigens in recurrent uveitis.