RT Journal Article
SR Electronic
T1 Lysophosphatidyl choline in the aqueous humour during ocular inflammation.
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 768
OP 770
DO 10.1136/bjo.63.11.768
VO 63
IS 11
A1 A G Secchi
A1 I Fregona
A1 F D'Ermo
YR 1979
UL http://bjo.bmj.com/content/63/11/768.abstract
AB Phospholipase A and lysophosphatidyl choline (LPC) have been shown to induce significant changes in the lens permeability in vitro to cations and soluble proteins. During uveal inflammation, in various experimental models and in man as well, the levels of LPC in the aqueous humour have been shown to reach values which are harmful to the lens in vitro. In addition, a phospholipase is thought to be activated during the antigen + antibody + complement sequence. The possible significance of these findings is discussed in relation to the pathogenesis of complicated cataracts in uveitis and the possible role of the lens as a source of autoantigens in recurrent uveitis.