RT Journal Article
SR Electronic
T1 Secretory IgA specific for herpes simplex virus in lacrimal fluid from patients with herpes keratitis--a possible diagnostic parameter.
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 648
OP 653
DO 10.1136/bjo.66.10.648
VO 66
IS 10
A1 Pedersen, B
A1 Møller Andersen, S
A1 Klauber, A
A1 Ottovay, E
A1 Prause, J U
A1 Zhong, C U
A1 Norrild, B
YR 1982
UL http://bjo.bmj.com/content/66/10/648.abstract
AB In the present study a solid-phase radioimmune assay was used for the demonstration of herpes simplex virus-specific IgG and secretory IgA antibodies in the lacrimal fluid from patients with active recurrent herpes keratitis. The method was quantitative and made it possible to test specifically for the production of secretory IgA antibodies produced during an active herpes simplex virus infection. The production of secretory IgA was followed in 2 patients with fresh recurrent lesions. The HSV-specific secretory IgA could be demonstrated during the first 10 days of infection, where the maximal concentration was reached 3-5 days after the first symptoms occurred. The secretory antibodies were locally produced, and it is shown for the first time that herpes virus-specific secretory antibodies were of diagnostic value.