RT Journal Article
SR Electronic
T1 Evidence for a neuropathic aetiology in the small pupil of diabetes mellitus.
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 89
OP 93
DO 10.1136/bjo.67.2.89
VO 67
IS 2
A1 S A Smith
A1 S E Smith
YR 1983
UL http://bjo.bmj.com/content/67/2/89.abstract
AB Infrared television pupillometry was performed on 34 insulin-treated diabetic patients and 55 healthy subjects. Sixteen of the diabetic patients had pupils that failed to dilate normally in darkness. The occurrence of a small pupil was associated with cardiac vagal dysfunction and somatic sensory loss. The small pupil was found to be supersensitive to the mydriatic effect of topical 2% phenylephrine but normally sensitive to 0.5% hydroxyamphetamine eyedrops. It is concluded that the failure of the pupil to dilate in darkness in some diabetic patients is due to neuropathy of the sympathetic innervation.