TY - JOUR T1 - Tapetoretinal degeneration in the cerebro-hepato-renal (Zellweger's) syndrome. JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 422 LP - 431 DO - 10.1136/bjo.66.7.422 VL - 66 IS - 7 AU - A. Garner AU - A. R. Fielder AU - R. Primavesi AU - A. Stevens Y1 - 1982/07/01 UR - http://bjo.bmj.com/content/66/7/422.abstract N2 - Electrophysiological and histopathological study of a baby suffering from Zellweger's syndrome and presenting progressive retinal dysfunction showed this to be related to degenerative changes in the photoreceptor cells and pigment epithelium and to defective myelination of the optic nerve. Disturbances of bile acid and lysine metabolism were also demonstrated, lending support to the concept that Zellweger's syndrome is attributable to a widespread inadequacy of intracellular oxidative function. ER -