PT  - JOURNAL ARTICLE
AU  - I A Chisholm
AU  - A E Chudley
TI  - Autosomal dominant iridogoniodysgenesis with associated somatic anomalies: four-generation family with Rieger's syndrome.
AID  - 10.1136/bjo.67.8.529
DP  - 1983 Aug 01
TA  - British Journal of Ophthalmology
PG  - 529--534
VI  - 67
IP  - 8
4099  - http://bjo.bmj.com/content/67/8/529.short
4100  - http://bjo.bmj.com/content/67/8/529.full
SO  - Br J Ophthalmol1983 Aug 01; 67
AB  - A family extending over 4 generations showed iridogoniodysgenesis accompanied by somatic malformations inherited in an autosomal dominant fashion. Iridogoniodysgenesis was present in 10 members, of whom 5 had established glaucoma; 4 youthful members are likely to develop glaucoma. Somatic malformations were present in 5 members from the 3rd and 4th generations who did not manifest iridogoniodysgenesis. A possible polygenic basis is discussed, though the variable expression of an autosomal dominant inheritance is still the more likely explanation.