TY - JOUR T1 - Autosomal dominant iridogoniodysgenesis with associated somatic anomalies: four-generation family with Rieger's syndrome. JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 529 LP - 534 DO - 10.1136/bjo.67.8.529 VL - 67 IS - 8 AU - I A Chisholm AU - A E Chudley Y1 - 1983/08/01 UR - http://bjo.bmj.com/content/67/8/529.abstract N2 - A family extending over 4 generations showed iridogoniodysgenesis accompanied by somatic malformations inherited in an autosomal dominant fashion. Iridogoniodysgenesis was present in 10 members, of whom 5 had established glaucoma; 4 youthful members are likely to develop glaucoma. Somatic malformations were present in 5 members from the 3rd and 4th generations who did not manifest iridogoniodysgenesis. A possible polygenic basis is discussed, though the variable expression of an autosomal dominant inheritance is still the more likely explanation. ER -