RT Journal Article
SR Electronic
T1 Binding potencies of 3 new beta 2 specific blockers to beta receptors in the ciliary processes and the possible relevance of these drugs to intraocular pressure control.
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 245
OP 247
DO 10.1136/bjo.68.4.245
VO 68
IS 4
A1 G E Trope
A1 B Clark
YR 1984
UL http://bjo.bmj.com/content/68/4/245.abstract
AB The binding potencies of 3 new beta 2 blocking drugs to beta receptors in the ciliary processes were studied by means of radioligand techniques. The drugs studied were IPS339, ICI118,551, and Sandoz L1 32-468. The order of potency of these drugs was IPS339 greater than Sandoz L1 32-468 greater than ICI118,551. The beta 2 dissociation constants (KDs) for these drugs were 0.90 nM, 6.60 nM, and 55 nM respectively. These results are compared with those for other adrenergic agents, including timolol. The potential role of topical beta 2 blockers in glaucoma is discussed.