PT  - JOURNAL ARTICLE
AU  - J S Lean
AU  - W A van der Zee
AU  - S J Ryan
TI  - Experimental model of proliferative vitreoretinopathy (PVR) in the vitrectomised eye: effect of silicone oil.
AID  - 10.1136/bjo.68.5.332
DP  - 1984 May 01
TA  - British Journal of Ophthalmology
PG  - 332--335
VI  - 68
IP  - 5
4099  - http://bjo.bmj.com/content/68/5/332.short
4100  - http://bjo.bmj.com/content/68/5/332.full
SO  - Br J Ophthalmol1984 May 01; 68
AB  - Silicone oil alone or as an adjunct to vitrectomy is widely used for the treatment of retinal detachment complicated by proliferative vitreoretinopathy (PVR). It appears to reduce the tendency for recurrent traction detachment, but the mechanism of this action is obscure. We have studied the effects of silicone oil in an experimental animal model. Twenty five thousand homologous fibroblasts were injected into the aphakic vitrectomised rabbit eye, and traction detachment of the vascularised retina (medullary rays) regularly resulted. Intraocular silicone oil did not influence the development of this experimental detachment.