RT Journal Article
SR Electronic
T1 Acanthamoeba keratitis successfully treated medically.
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 778
OP 782
DO 10.1136/bjo.69.10.778
VO 69
IS 10
A1 P Wright
A1 D Warhurst
A1 B R Jones
YR 1985
UL http://bjo.bmj.com/content/69/10/778.abstract
AB The first medical cure of a corneal infection due to an Acanthamoeba species is reported. The 44-year-old patient developed a suppurative keratitis associated with an epithelial defect, hypopyon, and secondary glaucoma. Acanthamoeba was confirmed as the causative agent four months after presentation when positive cultures were obtained from the cornea and from the conjunctiva. Sensitivity studies of the isolated organism were performed, and the infection was successfully controlled by treatment with a combination of dibromopropamidine and propamidine isethionate ointment and drops and neomycin drops. Keratoplasty was performed 22 months after onset, and no viable acanthamoebae were present in the resected tissue, though possible cyst remnants were identified by immunofluorescent techniques.