TY - JOUR T1 - Pharmacokinetics of a 5-fluorouracil liposomal delivery system. JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 688 LP - 691 DO - 10.1136/bjo.72.9.688 VL - 72 IS - 9 AU - S T Simmons AU - M B Sherwood AU - D A Nichols AU - R B Penne AU - T Sery AU - G L Spaeth Y1 - 1988/09/01 UR - http://bjo.bmj.com/content/72/9/688.abstract N2 - A liposomal delivery system was developed in an attempt to prolong ocular levels of 5-fluorouracil for glaucoma filtering surgery. The pharmacokinetics of the 5-fluorouracil liposomal delivery system were studied in normal pigmented rabbits with 5-fluorouracil labelled with carbon-14 (C-14). 14C 5-fluorouracil was incorporated into the liposomes at a concentration of 10 g/l and injected subconjunctivally in doses of 5 and 10 mg. Concentrations of 5-fluorouracil were assayed at 10 time intervals from 0.5 to 96 hours in cornea, sclera, and conjunctiva and at six time intervals from 0.5 to 12 hours in aqueous. Two peak concentrations were noted at approximately one and eight hours, with measurable levels present at 96 hours. This study demonstrates the ability of this liposomal delivery system to prolong levels of 5-fluorouracial in normal pigmented rabbits. ER -