PT  - JOURNAL ARTICLE
AU  - Jennings, T
AU  - Tessler, H H
TI  - Twenty cases of sympathetic ophthalmia.
AID  - 10.1136/bjo.73.2.140
DP  - 1989 Feb 01
TA  - British Journal of Ophthalmology
PG  - 140--145
VI  - 73
IP  - 2
4099  - http://bjo.bmj.com/content/73/2/140.short
4100  - http://bjo.bmj.com/content/73/2/140.full
SO  - Br J Ophthalmol1989 Feb 01; 73
AB  - We reviewed the charts of 20 patients with sympathetic ophthalmia who were seen in the uveitis clinic at the Eye and Ear Infirmary within an 11-year period. Of these 20 patients 14 maintained 20/50 or better visual acuity in at least one eye. We found early enucleation to be associated with a better visual prognosis, possibly due to earlier diagnosis and faster, more aggressive therapy rather than a reduction in antigenic load. The clinical appearance of Dalen-Fuchs nodules appears to indicate a more severe stage of disease. Chlorambucil was useful in patients with severe disease. To be effective and to lessen its side effects chlorambucil was given in daily dosages that were increased weekly over a short period to achieve bone marrow suppression. After a course of chlorambucil therapy intraocular inflammation could be controlled with topical steroids alone.