PT  - JOURNAL ARTICLE
AU  - Casswell, A G
AU  - McCartney, A C
AU  - Hungerford, J L
TI  - Choroidal malignant melanoma in an albino.
AID  - 10.1136/bjo.73.10.840
DP  - 1989 Oct 01
TA  - British Journal of Ophthalmology
PG  - 840--845
VI  - 73
IP  - 10
4099  - http://bjo.bmj.com/content/73/10/840.short
4100  - http://bjo.bmj.com/content/73/10/840.full
SO  - Br J Ophthalmol1989 Oct 01; 73
AB  - This is the first report of an amelanotic melanoma arising in the unpigmented choroid of a tyrosinase-positive oculocutaneous albino (TPOCA). Melanosomes within the tumour showed a maturation arrest in the unpigmented type II (premelanosome) phase. Other neural crest derived melanocytes in iris and choroid showed similar limited melanogenesis. The neuroectodermally derived melanocytes of the iris, ciliary body, and retinal pigment epithelium (RPE) contained mature melanosomes, though clinically the RPE was pale. The significance of this tumour arising in an albinotic eye is discussed.