PT  - JOURNAL ARTICLE
AU  - M J Menage
AU  - E de Clercq
AU  - A van Lierde
AU  - V S Easty
AU  - J M Darville
AU  - S D Cook
AU  - D L Easty
TI  - Antiviral drug sensitivity in ocular herpes simplex virus infection.
AID  - 10.1136/bjo.74.9.532
DP  - 1990 Sep 01
TA  - British Journal of Ophthalmology
PG  - 532--535
VI  - 74
IP  - 9
4099  - http://bjo.bmj.com/content/74/9/532.short
4100  - http://bjo.bmj.com/content/74/9/532.full
SO  - Br J Ophthalmol1990 Sep 01; 74
AB  - Thirty-nine herpes simplex virus (HSV) isolates were assayed for their sensitivity to 10 different antiviral agents. Of these 39 HSV isolates 10 were cultured from recipient buttons obtained at penetrating keratoplasty in patients with inactive stromal scarring due to recurrent herpetic keratitis, 25 were cultured from patients with conjunctival and ulcerative ocular infections, and the remaining four were laboratory strains with known drug sensitivity patterns, thus providing controls for the experiment. All but one of the 35 clinical isolates of HSV were type 1 and all were sensitive to the 10 antiviral agents. A single type 2 isolate from a young man with recurrent conjunctivitis proved to be resistant to a number of the antiviral agents. Since many of the clinical isolates had been exposed to multiple and protracted antiviral drug treatment, it is suggested that antiviral drug resistance in type 1 HSV ocular infection is not a significant problem.