RT Journal Article
SR Electronic
T1 Randomised single blind trial to compare the toxicity of subconjunctival gentamicin and cefuroxime in cataract surgery.
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 734
OP 738
DO 10.1136/bjo.74.12.734
VO 74
IS 12
A1 C D Jenkins
A1 P J McDonnell
A1 D J Spalton
YR 1990
UL http://bjo.bmj.com/content/74/12/734.abstract
AB Comparatively little attention has been paid to the conjunctival toxicity of antibiotics administered at the time of cataract surgery. We have observed the effect of subconjunctival gentamicin and cefuroxime injection, using colour photography in a randomised single blind trial of 121 patients undergoing routine cataract surgery. Our results suggest that a hyperaemic eye is likely to occur about twice as often in patients injected with gentamicin (p less than 0.001). Gentamicin is associated with more pain postoperatively (p less than 0.05). Significant manifestations of gentamicin toxicity are conjunctival oedema and capillary closure. Cefuroxime has some theoretical advantages over gentamicin in its antibacterial spectrum.