TY - JOUR T1 - Low dose cyclosporin A versus pulsed cyclophosphamide in Behçet's syndrome: a single masked trial. JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 241 LP - 243 DO - 10.1136/bjo.76.4.241 VL - 76 IS - 4 AU - Y. Ozyazgan AU - S. Yurdakul AU - H. Yazici AU - B. Tüzün AU - A. Işçimen AU - Y. Tüzün AU - T. Aktunç AU - H. Pazarli AU - V. Hamuryudan AU - A. Müftüoğlu Y1 - 1992/04/01 UR - http://bjo.bmj.com/content/76/4/241.abstract N2 - A single masked trial of cyclosporin A 5 mg/kg/day versus monthly 1 g intravenous boluses of cyclophosphamide was conducted among 23 patients with Behçet's syndrome and active, potentially reversible uveitis. The trial was unmasked after a mean of 12 (SD 2) months for the cyclosporin A group (n = 12) and a mean of 10 (SD 3) months for the cyclophosphamide group (n = 11). During the initial 6 months the visual acuity significantly improved (p < 0.001) in the cyclosporin A group whereas this was not observed in the cyclophosphamide group. The subsequent follow-up of patients up to 24 months suggested that the initial improvement in visual acuity with cyclosporin A was not sustained. More extensive and especially long-term studies of cyclosporin A in the uveitis of Behçet's syndrome are warranted. ER -