PT  - JOURNAL ARTICLE
AU  - Trew, D. R.
AU  - Wright, L. A.
AU  - Smith, S. E.
TI  - Ocular responses in healthy subjects to topical bunazosin 0.3%--an alpha 1-adrenoceptor antagonist.
AID  - 10.1136/bjo.75.7.411
DP  - 1991 Jul 01
TA  - British Journal of Ophthalmology
PG  - 411--413
VI  - 75
IP  - 7
4099  - http://bjo.bmj.com/content/75/7/411.short
4100  - http://bjo.bmj.com/content/75/7/411.full
SO  - Br J Ophthalmol1991 Jul 01; 75
AB  - The ocular effects of the alpha-adrenoceptor blocking drug bunazosin, administered as eyedrops, have been measured in a placebo-controlled double-blind single-dose study in 15 healthy volunteers. The drug significantly reduced intraocular pressure over 10 hours, and there was no associated change in pulsatile ocular blood flow. Characteristic effects of alpha-adrenoceptor blockade were observed--miosis, ptosis, and conjunctival hyperaemia. The miosis alone persisted for more than 24 hours in nine out of 15 subjects.