RT Journal Article
SR Electronic
T1 Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens.
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 171
OP 175
DO 10.1136/bjo.77.3.171
VO 77
IS 3
A1 A D Dick
A1 Y F Cheng
A1 A McKinnon
A1 J Liversidge
A1 J V Forrester
YR 1993
UL http://bjo.bmj.com/content/77/3/171.abstract
AB Current immunotherapy of posterior uveitis is non-specific and limited by drug toxicity and unpredictable relapses on therapy. Alternative modes of therapy being investigated using the rat model of experimental autoimmune uveoretinitis (EAU) have included the induction of tolerance with oral administration of milligram quantities of retinal antigens. In this preliminary report we demonstrate that tolerance to retinal antigens can be induced via the upper respiratory tract with microgram doses of antigen, preventing subsequent induction of EAU.