PT - JOURNAL ARTICLE AU - J Cano-Parra AU - M Diaz-Llopis AU - M J Maldonado AU - E Vila AU - J L Menezo TI - Prospective trial of intraoperative mitomycin C in the treatment of primary pterygium. AID - 10.1136/bjo.79.5.439 DP - 1995 May 01 TA - British Journal of Ophthalmology PG - 439--441 VI - 79 IP - 5 4099 - http://bjo.bmj.com/content/79/5/439.short 4100 - http://bjo.bmj.com/content/79/5/439.full SO - Br J Ophthalmol1995 May 01; 79 AB - AIMS--A prospective, randomised, double blind, placebo controlled study of intraoperative mitomycin C as adjunctive treatment of primary pterygium was conducted. METHODS--A total of 66 eyes of 54 patients with primary pterygium were treated with excision, with or without a single intraoperative application of mitomycin C (0.1 mg/ml for 5 minutes) to evaluate the efficacy and toxicity of this adjunctive treatment. The mean follow up was 14.1 months (range 12-23 months). RESULTS--Of the 36 eyes that underwent simple excision, 14 (38.8%) exhibited recurrences whereas only one of 30 eyes (3.33%) treated with excision and intraoperative application of mitomycin C had recurrence (p = 0.0006). Neither serious ocular complications nor systemic toxicity were noted in the mitomycin C treated group. CONCLUSION--Intraoperative mitomycin C appears to be an effective and safe adjunctive treatment of primary pterygium.