RT Journal Article
SR Electronic
T1 DNA index and S phase fraction in uveal malignant melanomas.
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 521
OP 526
DO 10.1136/bjo.79.6.521
VO 79
IS 6
A1 W G Hodge
A1 A J Duclos
A1 G Rocha
A1 E Antecka
A1 M G Baines
A1 C Corriveau
A1 S Brownstein
A1 J Deschenes
YR 1995
UL http://bjo.bmj.com/content/79/6/521.abstract
AB AIMS--To predict 5 year survival in patients with uveal malignant melanomas DNA indices were studied. METHODS--Using 45 paraffin embedded uveal malignant melanomas, the DNA index and S phase fraction of each tumour were the predictor variables recorded. RESULTS--Using the Cox proportional hazards model, aneuploid tumours and tumours which had an S phase fraction greater than 4% were significant predictors of early death. In order to demonstrate a biological gradient between a larger DNA index and shorter survival time, linear regression and transformed linear regression models were used. However, no such gradient could be demonstrated. CONCLUSION--Although this study shows promise for the use of DNA studies in the prognosis of uveal malignant melanoma, the exact role of these techniques remains to be determined.