TY - JOUR T1 - DNA index and S phase fraction in uveal malignant melanomas. JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 521 LP - 526 DO - 10.1136/bjo.79.6.521 VL - 79 IS - 6 AU - W G Hodge AU - A J Duclos AU - G Rocha AU - E Antecka AU - M G Baines AU - C Corriveau AU - S Brownstein AU - J Deschenes Y1 - 1995/06/01 UR - http://bjo.bmj.com/content/79/6/521.abstract N2 - AIMS--To predict 5 year survival in patients with uveal malignant melanomas DNA indices were studied. METHODS--Using 45 paraffin embedded uveal malignant melanomas, the DNA index and S phase fraction of each tumour were the predictor variables recorded. RESULTS--Using the Cox proportional hazards model, aneuploid tumours and tumours which had an S phase fraction greater than 4% were significant predictors of early death. In order to demonstrate a biological gradient between a larger DNA index and shorter survival time, linear regression and transformed linear regression models were used. However, no such gradient could be demonstrated. CONCLUSION--Although this study shows promise for the use of DNA studies in the prognosis of uveal malignant melanoma, the exact role of these techniques remains to be determined. ER -