RT Journal Article SR Electronic T1 Effects of short term increase of intraocular pressure on optic disc cupping JF British Journal of Ophthalmology JO Br J Ophthalmol FD BMJ Publishing Group Ltd. SP 880 OP 883 DO 10.1136/bjo.82.8.880 VO 82 IS 8 A1 Augusto Azuara-Blanco A1 Alon Harris A1 Louis B Cantor A1 Marcio M Abreu A1 Monika Weinland YR 1998 UL http://bjo.bmj.com/content/82/8/880.abstract AB AIMS To evaluate the effect of acute elevation of intraocular pressure (IOP) on optic disc cupping. METHODS 10 emmetropic and 10 myopic volunteers were included in this study. The cup area (CA) and cup volume (CV) of the optic disc were determined with the Heidelberg retina tomograph (HRT). After baseline determinations, a suction cup was used to increase the intraocular pressure (IOP) to 20–25 mm Hg above the baseline and HRT images were obtained. RESULTS Baseline IOP was 13.5 (SD 1.3) mm Hg and 12.6 (2.6) mm Hg in the emmetropic and myopic groups, respectively. The IOP was elevated to 35.4 (3.3) mm Hg and 34.4 (2.5) mm Hg in the emmetropic and myopic groups, respectively. When compared with their baseline values, the cupping variables (CA and CV) were significantly increased (p<0.05) during the suction treatment in both emmetropic and myopic subjects. CONCLUSION There was a significant enlargement in the optic disc cupping during the artificial increment of intraocular pressure in both emmetropic and myopic eyes. In non-glaucomatous eyes the optic nerve head has a partially dynamic topography dependent upon the level of IOP.