RT Journal Article
SR Electronic
T1 Case-control study of the risk factors for age related macular degeneration
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 996
OP 1002
DO 10.1136/bjo.82.9.996
VO 82
IS 9
A1 Gilles Chaine
A1 Alain Hullo
A1 José Sahel
A1 Gisèle Soubrane
A1 Marie-A Espinasse-Berrod
A1 Denys Schutz
A1 Christian Bourguignon
A1 Catherine Harpey
A1 Yves Brault
A1 Maylis Coste
A1 Dominique Moccatti
A1 Hubert Bourgeois
A1 for FRANCE-DMLA Study Group
YR 1998
UL http://bjo.bmj.com/content/82/9/996.abstract
AB AIM A case-control study was initiated to determine the risk factors for the development of age related macular degeneration (AMD). METHODS Study participants, who were all white, aged 50–85 years, and were recruited from private ophthalmology practices. Each practitioner enrolled patients with bilateral AMD, who were then matched with controls for sex and age. Environmental factors and systemic and ocular histories were screened. All patients had bilateral red-free fundus photographs and fluorescein angiography. Photographs were classified into pigment epithelium alterations, drusen, geographic atrophy, and exudative AMD. Statistical analysis included the identification of risk factors for AMD. A multivariate analysis was performed at the end of the study. Analysis included the entire study population and was carried out for each stage of AMD. RESULTS 1844 controls were compared with 1844 patients with AMD. Mean age was 71 years for controls and 72 for cases. Logistic regression identified six major risk factors for AMD (whole population): arterial hypertension (odds ratio (OR) =1.28), coronary disease (OR=1.31), hyperopia (OR=1.33), light coloured irises (OR=1.22), and lens opacities or previous cataract surgery (OR=1.55). The significance of vascular risk factors was increased for late stages of AMD, especially the atrophic forms (coronary disease, OR=3.19). CONCLUSIONS This large case-control study confirms some of the risk factors previously identified and may contribute to the determination of methods for prevention of AMD.