TY - JOUR T1 - Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 1183 LP - 1185 DO - 10.1136/bjo.83.10.1183 VL - 83 IS - 10 AU - Osman Çekiç AU - Cosar Batman AU - Ümit Yasar AU - Yüksel Totan AU - Nursabah E Basci AU - Atilla Bozkurt AU - Orhan Zilelioglu AU - S Oguz Kayaalp Y1 - 1999/10/01 UR - http://bjo.bmj.com/content/83/10/1183.abstract N2 - AIMS To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration. METHODS 31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received combined administration. Collected SRF samples were analysed for drug level by using high performance liquid chromatography. RESULTS SRF drug levels after oral and combined administration were significantly higher than that after topical administration (p=0.0002 and p=0.0002, respectively) while there was no significant difference between oral and combined administration (p=0.0844). CONCLUSIONS Ocular bioavailability of ofloxacin in SRF after oral and combined administration is equivalent. The addition of oral ofloxacin to topical therapy increased drug SRF penetration sixfold. ER -