PT  - JOURNAL ARTICLE
AU  - Osman Çekiç
AU  - Cosar Batman
AU  - Ümit Yasar
AU  - Yüksel Totan
AU  - Nursabah E Basci
AU  - Atilla Bozkurt
AU  - Orhan Zilelioglu
AU  - S Oguz Kayaalp
TI  - Penetration of topical, oral, and combined administered ofloxacin into the subretinal fluid
AID  - 10.1136/bjo.83.10.1183
DP  - 1999 Oct 01
TA  - British Journal of Ophthalmology
PG  - 1183--1185
VI  - 83
IP  - 10
4099  - http://bjo.bmj.com/content/83/10/1183.short
4100  - http://bjo.bmj.com/content/83/10/1183.full
SO  - Br J Ophthalmol1999 Oct 01; 83
AB  - AIMS To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration. METHODS 31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the other 11 patients received combined administration. Collected SRF samples were analysed for drug level by using high performance liquid chromatography. RESULTS SRF drug levels after oral and combined administration were significantly higher than that after topical administration (p=0.0002 and p=0.0002, respectively) while there was no significant difference between oral and combined administration (p=0.0844). CONCLUSIONS Ocular bioavailability of ofloxacin in SRF after oral and combined administration is equivalent. The addition of oral ofloxacin to topical therapy increased drug SRF penetration sixfold.