TY - JOUR T1 - Can leucocoria be the first manifestation of protein C deficiency? JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 117 LP - 117 DO - 10.1136/bjo.84.1.117d VL - 84 IS - 1 AU - EBRU ERGENEKON AU - BIRSIN SOLAK AU - GÜLYÜZ ÖZTÜRK AU - YILDIZ ATALAY AU - ESIN KOÇ Y1 - 2000/01/01 UR - http://bjo.bmj.com/content/84/1/117.5.abstract N2 - Editor,—Protein C is a plasma inhibitor protein that, once activated, inhibits clot formation and enhances fibrinolysis. Protein C deficiency has two forms. The homogeneous form presents in the neonatal period with ecchymotic-necrotic skin lesions and widespread thrombosis in major blood vessels with very low or undetectable protein C activity. Heterozygote individuals have protein C levels of approximately 50% and usually remain asymptomatic until adolescence.1 We present a neonate with homozygous protein C deficiency whose initial finding was leucocoria. CASE REPORT A 2 day old female infant was referred to Gazi University Hospital Division of Newborn Medicine with bullous … ER -