PT  - JOURNAL ARTICLE
AU  - Nicolai Christian Sjö
AU  - Steffen Heegaard
AU  - Jan Ulrik Prause
AU  - Christian von Buchwald
AU  - Henning Lindeberg
TI  - Human papillomavirus in conjunctival papilloma
AID  - 10.1136/bjo.85.7.785
DP  - 2001 Jul 01
TA  - British Journal of Ophthalmology
PG  - 785--787
VI  - 85
IP  - 7
4099  - http://bjo.bmj.com/content/85/7/785.short
4100  - http://bjo.bmj.com/content/85/7/785.full
SO  - Br J Ophthalmol2001 Jul 01; 85
AB  - AIM To examine conjunctival papillomas for the presence of human papillomavirus (HPV) and koilocytosis. METHODS Archival paraffin embedded tissue from 55 conjunctival papillomas was analysed for the presence of HPV by polymerase chain reaction and subsequent filter hybridisation. Histological sections of the 55 papillomas were evaluated for the presence of koilocytosis. RESULTS HPV was present in 48 of 52 (92%) β globin positive papillomas. HPV type 6/11 were found in 40 of 47 investigated papillomas and a double infection with HPV 6/11 and 16 was identified in a single papilloma. In six papillomas the HPV type could not be identified. Koilocytosis was present in 22 of 55 papillomas (40%). CONCLUSION There is a strong association between HPV and conjunctival papillomas. HPV type 6/11 is the most common HPV type in conjunctival papilloma. The sensitivity of koilocytosis as an indicator of HPV in conjunctival papilloma is low.