PT  - JOURNAL ARTICLE
AU  - Michele Vetrugno
AU  - Anna Maino
AU  - Giuseppina Cardia
AU  - Grazia Maria Quaranta
AU  - Luigi Cardia
TI  - A randomised, double masked, clinical trial of high dose vitamin A and vitamin E supplementation after photorefractive keratectomy
AID  - 10.1136/bjo.85.5.537
DP  - 2001 May 01
TA  - British Journal of Ophthalmology
PG  - 537--539
VI  - 85
IP  - 5
4099  - http://bjo.bmj.com/content/85/5/537.short
4100  - http://bjo.bmj.com/content/85/5/537.full
SO  - Br J Ophthalmol2001 May 01; 85
AB  - AIM To evaluate the effect of a high dose vitamin A and E supplementation on corneal re-epithelialisation time, visual acuity and haze following photorefractive keratectomy (PRK). METHODS Two groups of 20 patients who underwent myopic PRK were supplemented with either 25 000 IU retinol palmitate and 230 mg α tocopheryl nicotinate or a placebo. Clinical outcomes were evaluated up to 360 days. RESULTS In the vitamin treated group, re-epithelialisation time was significantly faster (p=0.029) and haze incidence was reduced (p=0.035), especially for high myopic corrections (p=0.043). This group also reported a significantly better uncorrected visual acuity (p=0.043). CONCLUSIONS High dose vitamin A and E oral supplementation may accelerate re-epithelialisation time and may reduce corneal haze formation after PRK.