PT  - JOURNAL ARTICLE
AU  - A K Leck
AU  - P A Thomas
AU  - M Hagan
AU  - J Kaliamurthy
AU  - E Ackuaku
AU  - M John
AU  - M J Newman
AU  - F S Codjoe
AU  - J A Opintan
AU  - C M Kalavathy
AU  - V Essuman
AU  - C A N Jesudasan
AU  - G J Johnson
TI  - Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis
AID  - 10.1136/bjo.86.11.1211
DP  - 2002 Nov 01
TA  - British Journal of Ophthalmology
PG  - 1211--1215
VI  - 86
IP  - 11
4099  - http://bjo.bmj.com/content/86/11/1211.short
4100  - http://bjo.bmj.com/content/86/11/1211.full
SO  - Br J Ophthalmol2002 Nov 01; 86
AB  - Background: A multicentre study was carried out in Ghana and southern India to determine the aetiology of suppurative keratitis in two regions located at similar tropical latitudes. Studies of fungal keratitis from the literature were reviewed. Methods: Patients presenting at rural and urban eye units with suspected microbial keratitis were recruited to the study. Corneal ulceration was defined as loss of corneal epithelium with clinical evidence of infection with or without hypopyon. Microscopy and culture were performed on all corneal specimens obtained. Results: 1090 patients were recruited with suspected microbial keratitis between June 1999 and May 2001. Overall the principal causative micro-organisms in both regions were filamentous fungi (42%): Fusarium species and Aspergillus species were the commonest fungal isolates. Pseudomonas species were most frequently isolated from cases of bacterial keratitis in Ghana but in India the commonest bacterial isolates were streptococci. Conclusion: Infections of the cornea due to filamentous fungi are a frequent cause of corneal damage in developing countries in the tropics and are difficult to treat. Microscopy is an essential tool in the diagnosis of these infections. A knowledge of the “local” aetiology within a region is of value in the management of suppurative keratitis in the event that microscopy cannot be performed.