PT - JOURNAL ARTICLE AU - A D Singh AU - I G Rennie AU - T Kivela AU - S Seregard AU - H Grossniklaus TI - The Zimmerman-McLean-Foster hypothesis: 25 years later AID - 10.1136/bjo.2003.029058 DP - 2004 Jul 01 TA - British Journal of Ophthalmology PG - 962--967 VI - 88 IP - 7 4099 - http://bjo.bmj.com/content/88/7/962.short 4100 - http://bjo.bmj.com/content/88/7/962.full SO - Br J Ophthalmol2004 Jul 01; 88 AB - It is now 25 years since the publication of the landmark article by Zimmerman, McLean, and Foster, in which they cast doubts on the benefit of enucleation, which was the prevailing management of choroidal melanoma at that time. Over the past 25 years several advances have been made in the management of uveal melanoma. Research in the pathobiology of cancer metastasis in general and uveal melanoma in particular has also provided new insights. In this review, the Zimmerman-McLean-Foster hypothesis is explored in the light of current clinical, epidemiological, statistical, and experimental evidence.