RT Journal Article
SR Electronic
T1 Infantile infection and diabetes insipidus in children with optic nerve hypoplasia
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1275
OP 1277
DO 10.1136/bjo.2005.069609
VO 89
IS 10
A1 S P Donahue
A1 A Lavina
A1 J Najjar
YR 2005
UL http://bjo.bmj.com/content/89/10/1275.abstract
AB Background: Bilateral optic nerve hypoplasia (BONH) is often associated with other central nervous system midline abnormalities (septo-optic dysplasia). Hormonal dysfunction, caused by anterior (cortisol) and posterior (ADH) pituitary involvement, can be sudden, severe, and life threatening. Methods: Case series. Three cases of septo-optic dysplasia (SOD) presenting as infantile infection with associated diabetes insipidus are reported. The diagnosis of SOD was suspected only after ophthalmological evaluation; further evaluation led to the diagnosis of panhypopituitarism. Conclusions: A high index of suspicion is required to diagnose SOD in children when the disorder presents with infantile infection and hypernatraemia. Early warning signs of neonatal jaundice and hypoglycaemia should prompt ophthalmological evaluation.