PT  - JOURNAL ARTICLE
AU  - J F J Logan
AU  - S J A Rankin
AU  - A J Jackson
TI  - Retinal blood flow measurements and neuroretinal rim damage in glaucoma
AID  - 10.1136/bjo.2003.034884
DP  - 2004 Aug 01
TA  - British Journal of Ophthalmology
PG  - 1049--1054
VI  - 88
IP  - 8
4099  - http://bjo.bmj.com/content/88/8/1049.short
4100  - http://bjo.bmj.com/content/88/8/1049.full
SO  - Br J Ophthalmol2004 Aug 01; 88
AB  - Aim: To assess retinal blood flow characteristics in subjects with normal tension glaucoma (NTG), primary open angle glaucoma (POAG), and a group of controls using the Heidelberg retina flowmeter (HRF). The vascular parameters were correlated against structural damage of the optic nerve head, assessed using the Heidelberg retina tomograph (HRT). Methods: HRF images were obtained in 76 subjects with NTG, 58 with POAG, and 38 controls. Optic nerve head images, acquired using the HRT, were analysed with Moorfields Regression Analysis software. The HRF variables, measured adjacent to a rim segment identified as “abnormal,” were compared with the vascular parameters of the “normal” rim segments. The HRF parameters of the segments identified as normal in glaucoma subjects were compared with matched control segments. Results: The glaucoma subjects had significantly lower retinal haemodynamics than the control subjects. There were no significant differences in the HRF parameters between the NTG and POAG subjects. The discs that had been identified as having abnormal segments had lower HRF values than those with a corresponding normal segment. The glaucoma subjects with normal rim segments had statistically significant lower velocity, flow, and volume measurements than the controls for each location sampled. Conclusion: This study shows a relation between structural damage of the optic nerve head and the level of retinal blood flow. The changes in the circulation could indicate that it may be an early marker of the pathological process.