RT Journal Article
SR Electronic
T1 Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 1060
OP 1063
DO 10.1136/bjo.2003.035345
VO 88
IS 8
A1 T Nagaoka
A1 N Kitaya
A1 R Sugawara
A1 H Yokota
A1 F Mori
A1 T Hikichi
A1 N Fujio
A1 A Yoshida
YR 2004
UL http://bjo.bmj.com/content/88/8/1060.abstract
AB Aim: To investigate changes in choroidal blood flow (CBF) in the foveal region in patients with type 2 diabetes. Methods: Laser Doppler flowmetry was used to determine the CBF in the foveal region in 70 patients with type 2 diabetes and 36 age and sex matched healthy subjects (control group). The patients were classified into three groups: 33 patients (33 eyes) with no diabetic retinopathy (NDR), 20 patients (20 eyes) with non-proliferative diabetic retinopathy and no macular oedema (NPDR/MO−), and 17 patients (17 eyes) with NPDR and MO (NPDR/MO+). Optical coherence tomography was also used to measure the foveal thickness. Results: The group averaged CBF values were 13.5 (4.9), 9.4 (2.5), 10.8 (4.8), and 5.6 (2.0) (arbitrary units) in the control, NDR, NPDR/MO−, and NPDR/MO+ groups, respectively. The group averaged CBF values in the NDR group decreased (30.2%; p<0.01) compared with the control group. The average CBF value in the NPDR/MO+ group was also significantly lower (48.2%; p<0.01) compared with that in the NPDR/MO− group. Conclusion: The CBF in the foveal region significantly decreases in patients with diabetes, especially those with macular oedema.