PT  - JOURNAL ARTICLE
AU  - B C Chauhan
AU  - D M Hutchison
AU  - R P LeBlanc
AU  - P H Artes
AU  - M T Nicolela
TI  - Central corneal thickness and progression of the visual field and optic disc in glaucoma
AID  - 10.1136/bjo.2004.062927
DP  - 2005 Aug 01
TA  - British Journal of Ophthalmology
PG  - 1008--1012
VI  - 89
IP  - 8
4099  - http://bjo.bmj.com/content/89/8/1008.short
4100  - http://bjo.bmj.com/content/89/8/1008.full
SO  - Br J Ophthalmol2005 Aug 01; 89
AB  - Aims: To determine whether central corneal thickness (CCT) is a significant predictor of visual field and optic disc progression in open angle glaucoma. Methods: Data were obtained from a prospective study of glaucoma patients tested with static automated perimetry and confocal scanning laser tomography every 6 months. Progression was determined using a trend based approach called evidence of change (EOC) analysis in which sectoral ordinal scores based on the significance of regression coefficients of visual field pattern deviation and neuroretinal rim area over time are summed. Visual field progression was also determined using the event based glaucoma change probability (GCP) analysis using both total and pattern deviation. Results: The sample contained 101 eyes of 54 patients (mean (SD) age 56.5 (9.8) years) with a mean follow up of 9.2 (0.7) years and 20.7 (2.3) sets of examinations every 6 months. Lower CCT was associated with worse baseline visual fields and lower mean IOP in the follow up. In the longitudinal analysis CCT was not correlated with the EOC scores for visual field or optic disc change. In the GCP analyses, there was a tendency for groups classified as progressing to have lower CCT compared to non-progressing groups. In a multivariate analyses accounting for IOP, the opposite was found, whereby higher CCT was associated with visual field progression. None of the independent factors were predictive of optic disc progression. Conclusions: In this cohort of patients with established glaucoma, CCT was not a useful index in the risk assessment of visual field and optic disc progression.