PT  - JOURNAL ARTICLE
AU  - N Plange
AU  - M Kaup
AU  - A Weber
AU  - K O Arend
AU  - A Remky
TI  - Retrobulbar haemodynamics and morphometric optic disc analysis in primary open-angle glaucoma
AID  - 10.1136/bjo.2006.099853
DP  - 2006 Dec 01
TA  - British Journal of Ophthalmology
PG  - 1501--1504
VI  - 90
IP  - 12
4099  - http://bjo.bmj.com/content/90/12/1501.short
4100  - http://bjo.bmj.com/content/90/12/1501.full
SO  - Br J Ophthalmol2006 Dec 01; 90
AB  - Background: Previous studies confirmed reduced retrobulbar haemodynamics in primary open-angle glaucoma (POAG). Aim: To investigate a correlation between retrobulbar haemodynamics and morphometric neuroretinal rim analysis in patients with POAG. Methods: 51 patients with POAG (mean (standard deviation (SD)) age 65 (11) years) were included in this clinical study. Blood flow velocities (peak systolic velocity (PSV) and end-diastolic velocity (EDV)) of the ophthalmic artery, central retinal artery (CRA), posterior ciliary arteries (PCA) and central retinal vein were measured using colour Doppler imaging (Siemens Sonoline Sienna, Erlangen, Germany). Optic disc morphometry was carried out using scanning laser tomography (Heidelberg Retinal Tomograph II Heidelberg Egineering Heidelberg, Germany). The stereometric parameters of the neuroretinal rim (rim area, rim volume, cup shape measure and retinal nerve fibre layer (RNFL) cross-sectional area) were used for analysis. Results: The PSV of the CRA was significantly (p<0.001) correlated with rim area (r = 0.50) and rim volume (r = 0.51). The minimum velocities of the central retinal vein were significantly (p<0.001) correlated with rim volume (r = 0.56) and RNFL cross-sectional area (r = 0.49). No correlations were found for the flow velocities of the ophthalmic artery and PCAs. Conclusion: Retrobulbar haemodynamics of the central retinal artery and vein are correlated with the neuroretinal rim damage in POAG.