PT  - JOURNAL ARTICLE
AU  - E H Souied
AU  - N Leveziel
AU  - G Querques
AU  - J Darmon
AU  - G Coscas
AU  - G Soubrane
TI  - Indocyanine green angiography features of malattia leventinese
AID  - 10.1136/bjo.2005.081802
DP  - 2006 Mar 01
TA  - British Journal of Ophthalmology
PG  - 296--300
VI  - 90
IP  - 3
4099  - http://bjo.bmj.com/content/90/3/296.short
4100  - http://bjo.bmj.com/content/90/3/296.full
SO  - Br J Ophthalmol2006 Mar 01; 90
AB  - Background/aim: Malattia leventinese (ML) is an inherited macular degeneration characterised by the presence of small radial drusen. Despite extensive descriptions of this study of the fundus, angiographic features of ML have been inadequately described. The aim is to describe the indocyanine green angiography (ICG) features observed in ML. Methods: 10 eyes from five consecutive ML patients (aged 27–44 years) were prospectively included. A complete ophthalmological examination including colour fundus photographs, autofluorescence, fluorescein angiography (FA), and ICG was performed. Results: ICG differentiated two types of drusen. Large round aggregated drusen were consistently hypofluorescent in the early phases and presented as hyperfluorescent spots surrounded by halos of hypofluorescence in the late phases. Conversely, small radial drusen were mostly hyperfluorescent in the early phases with decreased fluorescence in the late phases of the ICG sequence. FA also showed differences in staining between the two types of drusen. Conclusions: ICG angiography revealed marked differences between the large round and small radial drusen observed in ML. The large central drusen presented with an unusual pustuliform feature on the late phases of the ICG sequence. This distinct feature may be useful in the diagnosis of late stage disease when drusen consolidation could obscure the radial drusen.