TY - JOUR T1 - Do retinopathy signs in non-diabetic individuals predict the subsequent risk of diabetes? JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 301 LP - 303 DO - 10.1136/bjo.2005.084400 VL - 90 IS - 3 AU - T Y Wong AU - Q Mohamed AU - R Klein AU - D J Couper Y1 - 2006/03/01 UR - http://bjo.bmj.com/content/90/3/301.abstract N2 - Background/aims: Isolated retinopathy signs are common in non-diabetic individuals and have been shown to be associated with impaired glucose metabolism. In a cohort of people without diabetes, the association of these retinopathy signs and subsequent development of diabetes were examined. Methods: A population based cohort study of 7992 people aged 49–73 years without diabetes was conducted. Retinal photographs of these participants were evaluated for the presence of retinopathy signs according to a standardised protocol. Incident cases of diabetes were identified prospectively. Results: After a follow up of 3 years, 291 (3.6%) people developed incident diabetes. In the total cohort, retinopathy was not significantly associated with incident diabetes (4.7% v 3.6%, multivariable adjusted odds ratio (OR) 1.1, 95% confidence intervals (CI), 0.7 to 1.9). However, among participants with a positive family history of diabetes, retinopathy was associated with incident diabetes (10.4% v 4.8%, multivariable adjusted OR 2.3, 95% CI, 1.0 to 5.3). Among participants without a family history of diabetes, retinopathy was not associated with incident diabetes Conclusions: In individuals with a family history of diabetes, retinopathy signs predict subsequent risk of clinical diabetes. ER -