TY - JOUR T1 - Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 527 LP - 530 DO - 10.1136/bjo.2006.102418 VL - 91 IS - 4 AU - Mustafa Ünal AU - Mehmet Güven AU - Kazım Devranoğlu AU - Ahmet Özaydın AU - Bahadır Batar AU - Nevbahar Tamçelik AU - Ebru Eroğlu Görgün AU - Didar Uçar AU - Ahmet Sarıcı Y1 - 2007/04/01 UR - http://bjo.bmj.com/content/91/4/527.abstract N2 - Background: Genetic factors and oxidative damage have been shown to have a role in the development of primary open angle glaucoma (POAG). Aim: To determine the effects of genetic polymorphisms of glutathione S transferase (GST)M1 and GSTT1 on the risk of POAG in a Turkish population. Methods: Using a multiplex polymerase chain reaction (PCR), GSTM1 and GSTT1 gene polymorphisms were analysed in 144 patients with POAG and in 121 otherwise healthy controls of similar age. Results: The GSTM1 positive genotype and the GSTT1 null genotype had an increased risk of developing POAG (p<0.001, OR 2.93, 95% CI 1.66 to 5.20 and OR 4.25, 95% CI 2.30 to 7.80, respectively). The risk of glaucoma also increased significantly in subjects with a combination of GSTM1 positive and GSTT1 null genotypes (p<0.001, OR 3.46, 95% CI 1.64 to 7.38). Conclusion: The GSTM1 positive genotype and GSTT1 null genotype or the combination of both may be associated with the increased risk of development of POAG in the Turkish population. ER -