@article {Saito1642, author = {M Saito and T Iida and D Nagayama}, title = {Photodynamic therapy with verteporfin for age-related macular degeneration or polypoidal choroidal vasculopathy: comparison of the presence of serous retinal pigment epithelial detachment}, volume = {92}, number = {12}, pages = {1642--1647}, year = {2008}, doi = {10.1136/bjo.2007.137075}, publisher = {BMJ Publishing Group Ltd}, abstract = {Aim: To evaluate outcomes after photodynamic therapy (PDT) with verteporfin in Japanese patients with age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV) and compare results with the presence/absence of a retinal pigment epithelial detachment (PED). Methods: We retrospectively reviewed 183 eyes with subfoveal choroidal neovascularisation secondary to AMD with more than 3 months{\textquoteright} follow-up (range 3 to 36; mean 15.6). A serous PED developed in 44 of 183 eyes. Results: A total of 124 eyes (67.8\%) completed 12 months{\textquoteright} follow-up. In 49 eyes with typical AMD, the best-corrected visual acuity (BCVA) improved a mean of 0.48 line. A significant (p\<0.05 to p\<0.0005) decline in VA occurred in eyes with a serous PED during any 3-month period. In 75 eyes with PCV, the BCVA at 12 months improved a mean of 1.79 lines. There was no significant difference between the BCVA in 22 eyes with a PED and 53 eyes without a PED during any 3 months. Conclusions: In eyes with typical AMD, a serous PED was associated with a significant decline in BCVA compared with eyes without a serous PED. In eyes with PCV, the visual outcomes were unaffected by a serous PED. When PDT is administered, differentiating PCV from typical AMD using indocyanine green angiography is important.}, issn = {0007-1161}, URL = {https://bjo.bmj.com/content/92/12/1642}, eprint = {https://bjo.bmj.com/content/92/12/1642.full.pdf}, journal = {British Journal of Ophthalmology} }