RT Journal Article
SR Electronic
T1 Degree of angle closure and extent of peripheral anterior synechiae: an anterior segment OCT study
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 103
OP 107
DO 10.1136/bjo.2007.122572
VO 92
IS 1
A1 D H W Su
A1 D S Friedman
A1 J L S See
A1 P T K Chew
A1 Y-H Chan
A1 W P Nolan
A1 S D Smith
A1 D Huang
A1 C Zheng
A1 Y Li
A1 P J Foster
A1 T Aung
YR 2008
UL http://bjo.bmj.com/content/92/1/103.abstract
AB Aims: To evaluate the relationship between angle width as determined by anterior segment optical coherence tomography (AS-OCT) and the presence of peripheral anterior synechiae (PAS).Methods: This was a prospective observational case series in which 203 subjects with primary angle closure or open angles were recruited. Images of the nasal, temporal and inferior angles were obtained with AS-OCT in dark conditions. Subjects then underwent gonioscopy by an independent examiner who was masked to the AS-OCT findings. PAS were identified by gonioscopy and defined as abnormal adhesions of the iris to the angle that were at least half a clock hour in width and present to the level of the anterior trabecular meshwork or higher. The total clock hours of PAS were recorded.Results: Sixty-eight subjects (33.5%) were PACS, 76 subjects (37.4%) had PAC/PACG, 14 (6.9%) had primary open angle glaucoma, and 45 (22.2%) subjects were normal with open angles. There was a weak but significant correlation between the angle opening distance (AOD), trabecular iris space area (TISA) and angle recess area (ARA) with clock hours of PAS (Spearman’s correlation coefficients = −0.30, −0.32 and −0.32, respectively, p<0.001). The mean values of the AOD, TISA and ARA in the nasal, temporal and inferior quadrants were significantly less in eyes with PAS compared with those without (p<0.001, Mann–Whitney U test). Analysis by quadrant showed that these parameters were smaller in the nasal and temporal quadrants in eyes with PAS (p<0.01).Conclusions: Angle width determined by AS-OCT and the extent of PAS were weakly correlated, and angle width was significantly smaller in eyes with PAS.