%0 Journal Article %A Y Yoshida %A S Yamagishi %A S Ueda %A K Yoshimura %A S Okuda %A R Yamakawa %T Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis %D 2008 %R 10.1136/bjo.2007.124966 %J British Journal of Ophthalmology %P 93-94 %V 92 %N 1 %X Background/aims: The aim of the study was to evaluate whether aqueous humor levels of asymmetric dimethylarginine (ADMA) are associated with monocyte chemoattractant protein-1 (MCP-1).Methods: Aqueous humor levels of ADMA and MCP-1 were measured by high-performance liquid chromatography (HPLC) and ELISA, respectively, in 31 uveitis samples and nine cataract control samples.Results: Aqueous humor ADMA and MCP-1 levels were significantly higher in infectious or non-infectious uveitis patients than in controls (0.67±0.04 nmol/ml vs 0.55±0.03 nmol/ml vs 0.43±0. 04 nmol/ml (p<0.01) and 29.0±11.3 ng/ml vs 4.5±1.2 ng/ml vs 0.47±0.1 ng/ml (p<0.01), respectively). A positive correlation between ADMA and MCP-1 levels in aqueous humor was found in control and uveitis patients (r = 0.33, p<0.05).Conclusion: The results demonstrated that aqueous humor levels of ADMA were positively associated with MCP-1 in humans. Our present observations suggest that aqueous humor levels of ADMA may be a novel biomarker of inflammation in uveitis. %U https://bjo.bmj.com/content/bjophthalmol/92/1/93.full.pdf