TY - JOUR T1 - HLA-DR17 and Mooren’s ulcer in South India JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 179 LP - 181 DO - 10.1136/bjo.2007.127050 VL - 92 IS - 2 AU - J R Zelefsky AU - C J Taylor AU - M Srinivasan AU - S Peacock AU - R S Goodman AU - T Key AU - P G Watson AU - E T Cunningham Y1 - 2008/02/01 UR - http://bjo.bmj.com/content/92/2/179.abstract N2 - Objective: To investigate the association between Mooren’s ulcer and human leucocyte antigen (HLA) type DR17(3) in patients from the Tamil Nadu State of South India.Methods: Blood samples from 38 patients with Mooren’s ulcer and 45 age- and sex-matched controls were obtained prospectively. HLA-DR and HLA-DQ typing was performed by PCR using sequence-specific primers.Results: Fifteen (40%) of the patients with Mooren’s ulcer tested positive for HLA-DR17(3) compared with seven (16%) of the controls (p = 0.01). Seventeen (45%) of the patients also tested positive for the closely linked HLA-DQ2 compared with 11 (24%) of controls (p = 0.05). When adjusted for multiplicity, the correlation between HLA-DR17(3) and Mooren’s ulcer remained significant (p = 0.03).Conclusions: These data demonstrate an association between HLA-DR17(3) and Mooren’s ulcer in South Indian patients, supporting autoimmune theories about the pathogenesis of the disorder. ER -