PT  - JOURNAL ARTICLE
AU  - Yi, K
AU  - Mujat, M
AU  - Park, B H
AU  - Sun, W
AU  - Miller, J W
AU  - Seddon, J M
AU  - Young, L H
AU  - de Boer, J F
AU  - Chen, T C
TI  - Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration
AID  - 10.1136/bjo.2008.137356
DP  - 2009 Feb 01
TA  - British Journal of Ophthalmology
PG  - 176--181
VI  - 93
IP  - 2
4099  - http://bjo.bmj.com/content/93/2/176.short
4100  - http://bjo.bmj.com/content/93/2/176.full
SO  - Br J Ophthalmol2009 Feb 01; 93
AB  - Background/aims: To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomical changes in eyes with non-neovascular age-related macular degeneration (AMD) compared with time domain optical coherence tomography (TDOCT).Methods: Images were obtained from three eyes of three patients with AMD using an experimental SDOCT system. Both a titanium–sapphire (Ti:sapphire) laser and a superluminescent diode (SLD) were used as a broadband light source to achieve cross-sectional images of the retina. A qualitative and quantitative analysis was performed for structural changes associated with non-neovascular AMD. An automated algorithm was developed to analyse drusen area and volume from SDOCT images. TDOCT was performed using the fast macular scan (StratusOCT, Carl Zeiss Meditec, Dublin, California).Results: SDOCT images can demonstrate structural changes associated with non-neovascular AMD. A new SDOCT algorithm can determine drusen area, drusen volume and proportion of drusen.Conclusions: With new algorithms to determine drusen area and volume and its unprecedented simultaneous ultra-high speed ultra-high resolution imaging, SDOCT can improve the evaluation of structural abnormalities in non-neovascular AMD.