PT  - JOURNAL ARTICLE
AU  - C Küçükerdönmez
AU  - J Beutel
AU  - K U Bartz-Schmidt
AU  - F Gelisken
TI  - Treatment of chronic ocular hypotony with intraocular application of sodium hyaluronate
AID  - 10.1136/bjo.2008.143834
DP  - 2009 Feb 01
TA  - British Journal of Ophthalmology
PG  - 235--239
VI  - 93
IP  - 2
4099  - http://bjo.bmj.com/content/93/2/235.short
4100  - http://bjo.bmj.com/content/93/2/235.full
SO  - Br J Ophthalmol2009 Feb 01; 93
AB  - Aim: The aim of the study was to report the functional and morphological outcome of intraocular injection of sodium hyaluronate for treatment of chronic ocular hypotony (COH).Methods: We reviewed the digital chart records of patients with COH who had received one or more injections of intravitreal or intracameral sodium hyaluronate (1.4% or 2.3%). The changes in the best corrected visual acuity (BCVA) and intraocular pressure (IOP) after treatment were recorded.Results: Thirty-two eyes of 32 patients with a mean age of 56.8 years were analysed. Previous vitreoretinal surgery had been performed on all eyes for either ocular-penetrating trauma (six eyes), chronic uveitis (six eyes), full macular translocation (five eyes) or retinal detachment (15 eyes). Mean follow-up time after the first intraocular injection was 29.7 months. BCVA (logMAR) at the baseline and the last follow-up visit were 1.84 (SE 0.65) and 1.82 (SE 0.72), respectively (p = 0.87). The mean IOP at the baseline increased from 2.28 (SE 0.27) mmHg to 7.12 (SE 1.03) mmHg at the last visit (p<0.001). At the final follow-up, 20 eyes (62.5%) had an IOP higher than 5 mmHg and 24 eyes (75%) had an unchanged or improved BCVA.Conclusions: Stabilisation of the IOP and vision in some eyes with COH following vitreoretinal surgery can be achieved with intraocular injection of sodium hyaluronate. Large case-series and long-term follow-up are necessary to confirm the beneficial role of intraocular sodium hyaluronate injections in such eyes.