TY - JOUR T1 - Ocular manifestations associated with murine typhus JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 938 LP - 942 DO - 10.1136/bjo.2008.156059 VL - 93 IS - 7 AU - M Khairallah AU - S Ben Yahia AU - A Toumi AU - B Jelliti AU - C Loussaief AU - F B Romdhane AU - R Messaoud AU - M Chakroun Y1 - 2009/07/01 UR - http://bjo.bmj.com/content/93/7/938.abstract N2 - Aims: To characterise and analyse ocular manifestations associated with acute murine typhus (MT), an infectious disease caused by Rickettsia typhi.Methods: Nine consecutive patients (18 eyes) with serologically confirmed MT at the acute stage were enrolled in this prospective, non-comparative study. All patients underwent complete ophthalmic examination, including dilated biomicroscopic fundus examination, fundus photography, fluorescein angiography (FA) and indocyanine green (ICG) angiography.Results: Of nine patients, eight (88.9%) had bilateral ocular involvement related to MT, with (nā€Š=ā€Š3) or without (nā€Š=ā€Š5) associated ocular symptoms. Findings included mild vitreous inflammation (10 eyes; 55.6%), white retinal lesions (nine eyes; 50%), retinal haemorrhages (four eyes; 22.2%), retinal vascular leakage (seven eyes; 38.9%), hypofluorescent choroidal dots on FA and/or ICG angiography (11 eyes; 61.1%), optic-disc swelling (two eyes; 11.1%), optic neuritis (one eye; 5.6%) and optic-disc staining (11 eyes; 61.1%). All ocular findings had a self-limited course.Conclusion: Ocular involvement is frequently observed in acute MT. A systematic fundus examination, complemented by angiography in selected cases, may be helpful in establishing an early clinical diagnosis of the disease while serological testing is pending. ER -