TY - JOUR T1 - Photoreceptor status after antivascular endothelial growth factor therapy in exudative age-related macular degeneration JF - British Journal of Ophthalmology JO - Br J Ophthalmol SP - 622 LP - 626 DO - 10.1136/bjo.2008.151977 VL - 93 IS - 5 AU - K Sayanagi AU - S Sharma AU - P K Kaiser Y1 - 2009/05/01 UR - http://bjo.bmj.com/content/93/5/622.abstract N2 - Aims: To evaluate the photoreceptor layer status after antivascular endothelial growth factor (VEGF) therapy in choroidal neovascularisation (CNV) secondary to age-related macular degeneration (AMD) using spectral-domain optical coherence tomography (SD-OCT).Design: Prospective, consecutive case series.Methods: Twenty-three eyes of 22 patients with CNV secondary to AMD with foveal thickness less than 250 µm after treatment with anti-VEGF therapy and no obvious leakage on time domain OCT, and eight healthy subjects as controls, were imaged with at least one of four different SD-OCT devices. The inner and outer segment (IS/OS) photoreceptor layers were graded, and correlated with various characteristics including visual acuity.Results: The IS/OS layer was detected in eight eyes (35%) of patients with AMD and all eyes (100%) of the healthy control subjects (p = 0.002). Eyes in patients with AMD with preserved IS/OS had a significantly better BCVA and mean change in BCVA, and were more likely not to have had previous laser treatment compared with eyes with absent IS/OS.Conclusions: SD-OCT is a useful tool to visualise IS/OS status. IS/OS is often absent in patients who have received treatment with anti-VEGF therapy for CNV due to AMD. The IS/OS status after anti-VEFG therapy correlates with BCVA and mean change in vision. ER -