PT  - JOURNAL ARTICLE
AU  - da R Lucena, D
AU  - Ribeiro, J A S
AU  - Costa, R A
AU  - Barbosa, J C
AU  - Scott, I U
AU  - de Figueiredo-Pontes, L L
AU  - Jorge, R
TI  - Intraoperative bleeding during vitrectomy for diabetic tractional retinal detachment with versus without preoperative intravitreal bevacizumab (IBeTra study)
AID  - 10.1136/bjo.2008.151233
DP  - 2009 May 01
TA  - British Journal of Ophthalmology
PG  - 688--691
VI  - 93
IP  - 5
4099  - http://bjo.bmj.com/content/93/5/688.short
4100  - http://bjo.bmj.com/content/93/5/688.full
SO  - Br J Ophthalmol2009 May 01; 93
AB  - Aims: To compare the amount of intraoperative intraocular bleeding in patients with diabetes with macula-involving tractional retinal detachment (TRD) undergoing pars plana vitrectomy (PPV) with and without preoperative intravitreal bevacizumab (IVB) injection.Methods: An institutional study was carried out with consecutive patients with diabetic retinopathy and macula-involving TRD of recent (3 months) onset who were randomly assigned to PPV only (PPV group) or PPV combined with one IVB (1.5 mg/0.06 ml) injection 2 weeks prior to surgery (bevacizumab (BEV)/PPV group). All patients underwent 23-gauge PPV 3 weeks after baseline. The main outcome measure was erythrocyte count in the fluid retrieved from the vitrectomy cassette using a Neubauer counting chamber.Results: The study included 20 patients. The mean erythrocyte count was 14 865×103 (SD 19 332×103; median 4500×103) cells in the BEV/PPV group, and 176 240×103 (SD 108 375×103; median 166 600×103) cells in the PPV group. The mean erythrocyte count was significantly lower in the BEV/PPV group than in the PPV group (p<0.0001). No major adverse events were identified.Conclusion: Preoperative IVB injection was associated with reduced intraocular bleeding during 23-gauge PPV for diabetic macula-involving TRD. Further studies are needed to confirm our preliminary findings.Trial registration number: NCT00690768.