PT  - JOURNAL ARTICLE
AU  - Jiang, Shuhong
AU  - Liu, Xialin
AU  - Luo, Lixia
AU  - Qu, Bo
AU  - Huang, Xiangkun
AU  - Xu, Li
AU  - Lin, Ying
AU  - Ye, Shaobi
AU  - Liu, Yizhi
TI  - Elevated serum IL-23 correlates with intraocular inflammation after cataract surgery in patients with Vogt–Koyanagi–Harada disease
AID  - 10.1136/bjo.2009.169052
DP  - 2010 Aug 01
TA  - British Journal of Ophthalmology
PG  - 1078--1082
VI  - 94
IP  - 8
4099  - http://bjo.bmj.com/content/94/8/1078.short
4100  - http://bjo.bmj.com/content/94/8/1078.full
SO  - Br J Ophthalmol2010 Aug 01; 94
AB  - Purpose Patients with Vogt–Koyanagi–Harada (VKH) disease are known to have severe inflammation after cataract surgery. This study was designed to investigate the role of IL-17-producing T helper (Th17) cell-related pro-inflammatory cytokines on postoperative inflammation in VKH patients.Methods Serum from nine VKH patients and nine controls with age-related or congenital cataract was collected before and 1, 7, 30 and 90 days after surgery, and aqueous humor (AqH) at the commencement of surgery. Protein levels of IL-23, IL-27, IL-17 and IFN-γ in serum and AqH were measured by ELISA. A laser flare-cell photometer was used to quantify intraocular inflammation.Results Serum IL-23 levels were significantly increased in VKH compared with control patients and peaked at 1 day postoperative, decreased rapidly in the first week, then attenuated gradually. In VKH patients, serum levels of IFN-γ were elevated in the first week after surgery and IL-27 was upregulated in the first month. Importantly, serum IL-23 levels were strongly correlated with aqueous flare value (r=0.689; p=0.007) and cell counts (r=0.671; p=0.01) in VKH compared with control patients.Conclusions The data indicate that serum IL-23 levels are significantly elevated in VKH compared with control patients and are strongly associated with postoperative intraocular inflammation.