RT Journal Article
SR Electronic
T1 Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study
JF British Journal of Ophthalmology
JO Br J Ophthalmol
FD BMJ Publishing Group Ltd.
SP 564
OP 568
DO 10.1136/bjo.2009.166793
VO 94
IS 5
A1 Saeed, Peerooz
A1 Blank, Leo
A1 Selva, Dinesh
A1 Wolbers, John G
A1 Nowak, Peter J C M
A1 Geskus, Ronald B
A1 Weis, Ezekiel
A1 Mourits, Maarten P
A1 Rootman, Jack
YR 2010
UL http://bjo.bmj.com/content/94/5/564.abstract
AB Background/aims To report the outcome of primary radiotherapy in patients with progressive optic nerve sheath meningioma (ONSM).Methods The clinical records of all patients were reviewed in a retrospective, observational, multicentre study.Results Thirty-four consecutive patients were included. Twenty-six women and eight men received conventional or stereotactic fractionated radiotherapy, and were followed for a median 58 (range 51–156) months. Fourteen eyes (41%) showed improved visual acuity of at least two lines on the Snellen chart. In 17 (50%) eyes, the vision stabilised, while deterioration was noted in three eyes (9%). The visual outcome was not associated with age at the time of radiotherapy (p=0.83), sex (p=0.43), visual acuity at the time of presentation (p=0.22) or type of radiotherapy (p=0.35). Optic disc swelling was associated with improved visual acuity (p<0.01) and 4/11 patients with optic atrophy also showed improvement. Long-term complications were dry eyes in five patients, cataracts in three, and mild radiation retinopathy in four.Conclusion Primary radiotherapy for patients with ONSM is associated with long-term improvement of visual acuity and few adverse effects.